Detalhe da pesquisa
1.
Identification of cap-dependent endonuclease inhibitors with broad-spectrum activity against bunyaviruses.
Proc Natl Acad Sci U S A
; 119(36): e2206104119, 2022 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36037386
2.
The impact of PA/I38 substitutions and PA polymorphisms on the susceptibility of zoonotic influenza A viruses to baloxavir.
Arch Virol
; 169(2): 29, 2024 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38216710
3.
Baloxavir Marboxil for Prophylaxis against Influenza in Household Contacts.
N Engl J Med
; 383(4): 309-320, 2020 07 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32640124
4.
Pharmacokinetic and pharmacodynamic analysis of baloxavir marboxil, a novel cap-dependent endonuclease inhibitor, in a murine model of influenza virus infection.
J Antimicrob Chemother
; 76(1): 189-198, 2021 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33035324
5.
Open-label study of the safety, pharmacokinetics, and effectiveness of a 2 mg/kg dose of baloxavir marboxil 2% granules in children <20 kg with influenza.
J Infect Chemother
; 27(8): 1223-1229, 2021 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-34045119
6.
Dihydrodibenzothiepine: Promising hydrophobic pharmacophore in the influenza cap-dependent endonuclease inhibitor.
Bioorg Med Chem Lett
; 30(22): 127547, 2020 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32927030
7.
Combination treatment with the cap-dependent endonuclease inhibitor baloxavir marboxil and a neuraminidase inhibitor in a mouse model of influenza A virus infection.
J Antimicrob Chemother
; 74(3): 654-662, 2019 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30476172
8.
Antiviral activity of stachyflin on influenza A viruses of different hemagglutinin subtypes.
Virol J
; 10: 118, 2013 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23587221
9.
In Vivo Antiviral Activity of Baloxavir against PA/I38T-Substituted Influenza A Viruses at Clinically Relevant Doses.
Viruses
; 15(5)2023 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37243240
10.
Prophylactic Treatment with Baloxavir Protects Mice from Lethal Infection with Influenza A and B Viruses.
Viruses
; 15(11)2023 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38005940
11.
Characterization of the In Vitro and In Vivo Efficacy of Baloxavir Marboxil against H5 Highly Pathogenic Avian Influenza Virus Infection.
Viruses
; 14(1)2022 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35062315
12.
Carryover effects of baloxavir acid in human nasopharyngeal/pharyngeal swabs on infectious titer testing of influenza virus.
Influenza Other Respir Viruses
; 14(3): 353-357, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31994309
13.
Baloxavir marboxil, a novel cap-dependent endonuclease inhibitor potently suppresses influenza virus replication and represents therapeutic effects in both immunocompetent and immunocompromised mouse models.
PLoS One
; 14(5): e0217307, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31107922
14.
Inhibition of avian-origin influenza A(H7N9) virus by the novel cap-dependent endonuclease inhibitor baloxavir marboxil.
Sci Rep
; 9(1): 3466, 2019 03 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30837531
15.
Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.
Sci Rep
; 8(1): 9633, 2018 06 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29941893
16.
In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit.
Antiviral Res
; 160: 109-117, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30316915
17.
Therapeutic efficacy of peramivir against H5N1 highly pathogenic avian influenza viruses harboring the neuraminidase H275Y mutation.
Antiviral Res
; 139: 41-48, 2017 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-28012921
18.
The relationship between in vivo antiviral activity and pharmacokinetic parameters of peramivir in influenza virus infection model in mice.
Antiviral Res
; 109: 110-5, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24997412
19.
A strategy for neuraminidase inhibitors using mechanism-based labeling information.
Chem Asian J
; 6(4): 1048-56, 2011 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21305698
20.
Secondary mutations in viruses resistant to HIV-1 integrase inhibitors that restore viral infectivity and replication kinetics.
Antiviral Res
; 81(2): 141-6, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19027039